Abstract Novel Heterogenous and Magneticaly Separable Catalysts for Selective and Enantioselective Organic Transformations

NOVEL HETEROGENOUS AND MAGNETICALY SEPARABLE CATALYSTS FOR SELECTIVE AND ENANTIOSELECTIVE ORGANIC TRANSFORMATIONS A brief description of the chapters in the thesis is outlined below: Chapter 1 Chapter 2 Chapter 5 Chapter 3 Chapter 4 Section B Section A THESIS CHAPTER-I, describes the various catalysts/process options available for an industrial chemist to effect different organic transformations. It includes a brief introduction of homogeneous catalysis, heterogeneous catalysis, asymmetric catalysis, nanomaterials and nanocatalysis. The need and development of cleaner and greener alternative technologies using truly heterogeneous catalytic systems in the synthesis of pharmaceuticals and fine chemicals is described. CHAPTER-II, describes the design and development of nanocrystalline copper(II) oxide for the N-arylation of heterocycles with iodo-, bromo-, chloroand fluoroarenes to afford N-arylheterocycles with good yields under ligand free conditions (Scheme 1). The catalyst is recovered by simple centrifugation, and the efficiency of the catalyst remains almost unaltered even after several cycles. X Het-NH Nano-CuO, 120 oC DMF, K2CO3 R + X = Cl, F N-Het R R = electron withdrawing group Scheme 1 X Het-NH Nano-CuO, 110 oC DMSO, KOH R + X = I, Br N-Het R R = electron withdrawing and electron donating group 21 88% yield